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HelpOrderable Name RISAP Risankizumab Quantitation with Antibodies, Serum
Specimen Required
Patient Preparation: For 12 hours before specimen collection, patient should not take multivitamins or dietary supplements (eg, hair, skin, and nail supplements) containing biotin (vitamin B7).
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 1.5 mL
Collection Instructions:
1. Draw blood immediately before next scheduled dose (trough specimen).
2. Within 2 hours of collection, centrifuge, and aliquot serum into a plastic vial.
Useful For
Evaluation of patients with limited primary (initial) response to or secondary loss of response to risankizumab
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| RISA | Risankizumab, S | Yes | Yes |
| RISAB | Risankizumab Ab, S | No | Yes |
Testing Algorithm
For more information see Ulcerative Colitis and Crohn Disease Therapeutic Drug Monitoring Algorithm.
Special Instructions
Method Name
RISA: Liquid Chromatography Mass Spectrometry (LC-MS)
RISAB: Electrochemiluminescent-Bridging Immunoassay (ECLIA)
Specimen Type
SerumSpecimen Minimum Volume
0.75 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 28 days | |
| Frozen | 28 days |
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | Reject |
| Gross icterus | OK |
| Heat-treated specimens | Reject |
Reference Values
RISANKIZUMAB QUANTITATION:
Risankizumab lower limit of quantitation =1.0 mcg/mL
RISANKIZUMAB ANTIBODIES:
Antibodies to risankizumab: <20.0 ng/mL
Day(s) Performed
Weekly
Report Available
2 to 9 daysCPT Code Information
80299
82397
Forms
If not ordering electronically, complete, print, and send Gastroenterology and Hepatology Test Request (T728) with the specimen.