Orderable Name LBCS Labile Bound Copper, Serum
Ordering Guidance
If CUS1 / Copper, Serum is ordered with this test, it will be canceled, as copper testing will be automatically added as a part of this test order.
Specimen Required
Patient Preparation: High concentrations of gadolinium and iodine are known to potentially interfere with most inductively coupled plasma mass spectrometry-based metal tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for at least 96 hours.
Supplies:
-Metal Free Specimen Vial (T173)
-Metal Free B-D Tube (No Additive), 6 mL (T184)
Collection Container/Tube: 6-mL Plain, royal blue-top Vacutainer plastic trace element blood collection tube
Submission Container/Tube: 7-mL Metal-free, screw-capped, polypropylene vial
Specimen Volume: 0.75 mL
Collection Instructions:
1. For complete instructions, see Metals Analysis Specimen Collection and Transport.
2. Allow the specimen to clot for 30 minutes; then centrifuge the specimen to separate serum from the cellular fraction.
3. Remove the stopper. Carefully pour specimen into metal-free, polypropylene vial, avoiding transfer of the cellular components of blood. Do not insert a pipet into the serum to accomplish transfer, and do not ream the specimen with a wooden stick to assist with serum transfer.
4. Freeze sample on dry ice immediately after pouring off the serum.
Useful For
May be useful in the evaluation of copper-related disorders, including Wilson disease
Additional Tests
Test ID | Reporting Name | Available Separately | Always Performed |
---|---|---|---|
CUS1 | Copper, S | Yes | Yes |
Testing Algorithm
After a labile bound copper serum result is obtained, a total copper serum test will be performed at an additional charge. The labile bound copper concentration will be divided by the total copper concentration to calculate the labile bound copper fraction result.
Special Instructions
Method Name
Inductively-Coupled Plasma Mass Spectrometry (ICP-MS)
Specimen Type
SerumSpecimen Minimum Volume
0.5 mL
Specimen Stability Information
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Serum | Frozen | 28 days | METAL FREE |
Reject Due To
Gross hemolysis | OK |
Gross lipemia | OK |
Gross icterus | Reject |
Reference Values
Labile Bound Copper: <105 ng/mL
Labile Bound Copper Fraction:
Males: <10.5 %
Females: <8.1 %
Copper, Total:
0-2 months: 40-140 mcg/dL
3-6 months: 40-160 mcg/dL
7-9 months: 40-170 mcg/dL
10-12 months: 80-170 mcg/dL
13 months-10 years: 80-180 mcg/dL
11-17 years: 75-145 mcg/dL
Males:
≥18 years: 73-129 mcg/dL
Females:
≥18 years: 77-206 mcg/dL
Day(s) Performed
Wednesday
Report Available
7 to 14 daysCPT Code Information
82525