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Orderable Name INSAL Insulin Analogs, Serum


Specimen Required


Patient Preparation:

Fasting: 8 hours, required for human insulin reference values to apply

Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube:

Preferred: Red Top

Acceptable: Serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 1.5 mL Serum

Collection Instructions: Within 2 hours of collection, centrifuge and aliquot serum into a plastic vial

Additional Information: Human insulin reference values are not applicable to patients who were not fasting for 8 hours or received pharmaceutical/synthetic insulin analogs.


Useful For

Detection and quantitation of native human insulin and insulin analogs in serum

 

Assessment of factitious hypoglycemia from misuse or surreptitious administration of insulin analogs

 

Monitoring treatment adherence of prescribed insulin therapy

 

Providing an alternative testing methodology for insulin measurements when immunoassay test results do not align with the clinical presentation and/or interference is suspected

Method Name

Liquid Chromatography Mass Spectrometry, High-Resolution Accurate Mass-Mass Spectrometry (LC-MS HRAM)

Specimen Type

Serum Red

Specimen Minimum Volume

Serum: 0.75 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Red Frozen 14 days

Reject Due To

Gross hemolysis Reject
Gross lipemia OK
Gross icterus OK

Reference Values

Human insulin: 2.6-24.9 mcIU/mL

Reference values only apply to fasting patients not being administered pharmaceutical/synthetic insulins.

 

Therapeutic reference intervals for synthetic insulin analogs have not been established.

Report Available

10 days

CPT Code Information

G0480

80375 (if appropriate for select payers)