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HelpOrderable Name HTGR Thyroglobulin, Tumor Marker Reflex, Serum
Useful For
Reporting of accurate thyroglobulin results, depending on the antithyroglobulin antibodies status of the patient
Accurate measurement of serum thyroglobulin in patients with known or suspected antithyroglobulin autoantibodies or possible heterophile antibodies
Testing Algorithm
This test begins with the analysis of thyroglobulin antibody by immunoassay. If the thyroglobulin antibody result is negative (<1.8 IU/mL), then thyroglobulin testing will be performed by immunoassay.
If the thyroglobulin antibody result is positive (≥1.8 IU/mL), then thyroglobulin testing will be performed by mass spectrometry.
Specimen Type
Serum RedSpecimen Required
Patient Preparation: For 12 hours before specimen collection, patient should not take multivitamins or dietary supplements (eg, hair, skin, and nail supplements) containing biotin (vitamin B7).
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube:
Preferred: Red top
Acceptable: None (serum gel/SST are not acceptable)
Submission Container/Tube: Plastic vial
Specimen Volume: 2 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Specimen Minimum Volume
1.25 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum Red | Refrigerated (preferred) | 7 days |
| Frozen | 30 days | |
| Ambient | 72 hours |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | OK |
| Gross icterus | Reject |
Reference Values
THYROGLOBULIN ANTIBODY
<1.8 IU/mL
THYROGLOBULIN, TUMOR MARKER
≤33 ng/mL
Day(s) Performed
Monday through Saturday
Report Available
1 to 6 daysCPT Code Information
86800
84432 (if appropriate)
Reflex Tests
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| HTGT | Thyroglobulin, Tumor Marker, IA, S | No | No |
| TGMS | Thyroglobulin, Mass Spec., S | Yes | No |
Method Name
HTGT: Immunoenzymatic Assay
TGMS: Tryptic Protein Fragmentation, purified with Immunocapture, Analysis by Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) (This service is performed pursuant to an agreement with SISCAPA Assay Technologies Inc. covering US Patent 7,632,686)
Forms
If not ordering electronically, complete, print, and send an Oncology Test Request (T729) with the specimen.