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Orderable Name HIAAP 5-Hydroxyindoleacetic Acid, Plasma


Ordering Guidance


This test quantifies 5-hydroxyindoleacetic acid in plasma specimens and is comparable to testing on 24-hour and random urine specimens for the diagnosis and monitoring of intestinal carcinoid syndrome.



Necessary Information


Patient's age is required.



Specimen Required


Patient Preparation:

1. Some medications could interfere with test results. If medically feasible, for 48 hours before and during specimen collection, patient should not take the following medications:

-Acetaminophen (Tylenol or generic versions)

-Tryptophan containing supplements.

2. For 24 hours prior to and during collection, the patient should limit the following to one serving per day:

-Fruits

-Vegetables

-Caffeinated beverages or foods

3. For 24 hours prior to and during collection, patients should not eat nuts, especially walnuts. Plasma 5-hydroxyindoleacetic acid levels revert to baseline levels when walnuts are ingested after other foods.

 

Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube:

Preferred: Green top (sodium heparin)

Acceptable: Lavender top (EDTA)

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions:

1. Centrifuge at 4° C.

2. Aliquot plasma into plastic vial.

3. Send plasma frozen.


Useful For

Biochemical diagnosis and monitoring of intestinal carcinoid syndrome using a plasma specimen

Method Name

Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)

Specimen Type

Plasma

Specimen Minimum Volume

0.2 mL

Specimen Stability Information

Specimen Type Temperature Time
Plasma Frozen (preferred) 60 days
  Refrigerated  72 hours

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Reference Values

≤6 months: ≤130 ng/mL

>6 months: ≤30 ng/mL

Day(s) Performed

Monday, Wednesday, Thursday, Friday

Report Available

2 to 4 days

CPT Code Information

83497