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Orderable Name CZPS Clonazepam and 7-Aminoclonazepam, Serum

Additional Codes

CNE Order Code: Clonazepam

Test Down Notes

This test is temporarily unavailable due to instrumentation issues. As an alternate, order FCLMS. For additional details, see test update here.

Useful For

Assessing patient compliance

 

Monitoring for appropriate therapeutic level

 

Assessing clonazepam toxicity

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Specimen Type

Serum Red


Specimen Required


Collection Container/Tube: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1.2 mL

Collection Instructions:

1. Draw blood immediately before next scheduled dose (minimum 12 hours after last dose).

2. Within 2 hours of collection, the specimen must be centrifuged and the serum aliquoted into a plastic vial.


Specimen Minimum Volume

0.6 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Red Refrigerated (preferred) 14 days
  Frozen  28 days
  Ambient  72 hours

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus Reject

Reference Values

Clonazepam

Anticonvulsant: 20-70 ng/mL

Anxiolytic: 4-80 ng/mL

Some individuals may show therapeutic response outside of these ranges or may display toxicity within the therapeutic range, thus interpretation should include clinical evaluation. 

Note: Therapeutic ranges are for specimens collected at trough (ie, immediately before next scheduled dose). Levels may be elevated in non-trough specimens.

Day(s) Performed

Monday, Wednesday

Report Available

3 to 7 days

CPT Code Information

80299

Forms

If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.